So much for evidence-based medicine. Ive talked to doctors who are extremely familiar with the drug and all the trial results and they would prescribe it to their patients. Kirsch told me that meta-analyses are a higher level of evidence than randomized controlled trials. When I responded that meta-analyses are only as good as the data they are based on, he said Id like to understand your source on that, because I cant find a source that says a phase 3 trial is greater evidence than a meta-analysis., When you characterize me, you need to say that Steve Kirsch doesn't go with majority votes on interpreting data.. Food/drugs to avoid while on fluvoxamine. . Their willingness to lie did. Drug researchers at Washington University in St. Louis reached out to Kirsch looking for $67,000 to finish a very smallbut placebo-controlledtrial. Entrepreneur Steve Kirsch who holds an early patent for the optical mouse decided to get involved in treating Covid. thinks it should be used (and that the NIH is wrong for waiting for more clinical trials). This is quite stunning because the PK of the drug done at the Gates Foundation shows it only reaches 50% of the final concentration after 3 days. Reason is the hospital gets release from liability if they follow NIH guidelines. Quick Summary . saying that the per-protocol analysis was arbitrary and other excuses. It was recommended back in January 2021 by a key opinion leader (KOL) panel to be used, but it took a year for, because they were rejected by 10 journals. It should be crystal clear to everyone that the current CDC guidelines for treating COVID aren't working. In short, a lot of mumbo jumbo. How can we get fluvoxamine? The most stunning study of fluvoxamine ever done was at the Golden Gate Fields racetrack in November 2020, right after the WashU trial was published in JAMA. There are two ways Ive discovered that I may be able to save the world, he told an IEEE Spectrum reporter in 2000. What's even worse is that a third of recovered patients from COVID will return to the hospital within 5 months and 1 in 8 die. The incident, he added, was completely in keeping with his personality.. Doctors have no excuse for not prescribing. Hes adept at debate, rapidly shifting the premise of a conversation to put the other person on the back foot. Steve and CETF funded the research that showed promising results of fluvoxamine as an early treatment of COVID-19. Their willingness to lie did. But even she was drained by Kirschs constant attempts to override the data. Those days are gone. I was just getting tired, he said, before asking to speak off the record. Its all about NIH saying it is OK. Medicine today is driven by government opinion, not science. They were giving covid patients the antidepressant fluvoxamine as soon as possible after diagnosis, based on anecdotes about the drug limiting the runaway immune response that causes many severe symptoms. One is to reduce the threat of nuclear war. To vet proposals, he recruited a powerhouse advisory board of prominent biologists, drug developers, and clinical researchers, led by world-renowned drug researcher Robert Siliciano of Johns Hopkins. Timing is everything with respect to outcomes. Note that some of these articles are inaccurate. Some people are jittery, but usually that is because the doctor either prescribed a dosage higher than 50mg twice a day or didnt notify the patient to. But a panel of key opinion leaders from the NIH, CDC . The Lancet paper showed that if you were treated early enough and took the drug as prescribed (it only works if you take it), it was shown to reduce your chance of death by 12X making it far more effective than any other drug for COVID. But they will refuse to give it to you even after being proven in a Phase 3 trial that was approved by the WHO. While YouTube has repeatedly taken down the full video of the DarkHorse episode, various clips have been watched over 4 million times, and the full audio remains available on Spotify. Those days are gone. Download Citation | On Mar 1, 2023, Gne Seda Albayrak and others published A Cross-Sectional Study on the Personality Traits of Episodic and Chronic Migraine Patients | Find, read and cite all . Server IP address resolved: Yes Http response code: 200 Response time: 0.27 sec. I will . The man who ran Risperdal sales, Alex Gorsky, is now CEO of Johnson & Johnson. He was recently featured on 60 Minutes which highlighted his . Its motivated out of his sense of keeping people safe and advancing health care.. If you cant lay off the java, then try fluoxetine (Prozac). Steve calls himself a "medical philanthropist" who says "the most important thing to me is saving lives." In . How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. His foundation shifted focus to one goalcuring Steve Kirschby supporting one of the few scientists looking at the disease. Fluvoxamine has at least a 30% hospitalization and death benefit. In that same IEEE Spectrum story about his then-new startup, Propel Software, he said he felt successful, but not famous. Steve Kirsch is a high-tech serial entrepreneur based in Silicon Valley. Be warned!. Doing something is better than nothing. Telling the truth, he tweeted. So you can address your OCD and if you get COVID, youll can up the dose. He retired at the largest pension in federal history. He immediately tweeted an offer to give anyone $1 million if they could win a debate with him about vaccine deaths. . No long haul symptoms if you start the drug ASAP after first symptoms. Compulsive hand washing? My experience is very typical. (Clayton Fox, Marty Makary, and Jeffrey Klausner). See the repository above. Skirsch.io Steve Kirsch Home page Fluvoxamine, COVID, pandemic, . To date, we have heard nothing suggesting the drug doesn't work or could be harmful. I have never heard of a case it didn't work. Here are the key things you should know about fluvoxamine for COVID: It works. It cant be more clear than this. When was the last time you saw a phase 3 fail where there was a 100% effect size in both an RCT and RWE study along with 4 independent observational trials all showing a positive effect, and there is clear mechanism of action where there is less than a 1% chance that it is not working (the SSRI's ordered their impact based on their Sigma activation which is 1 in 120 options), and where in every single case we are aware of the patient taking the drug reversed to normal in an average of 3 days? Vitamin D, NAC, betadine, aspirin, and Nigella sativa are all super cheap, effective, and available without a prescription. . That was a lie. Design thinking was supposed to fix the world. As of November 13, fluvoxamine has been proven to work in every trial that has published results, including outpatient and inpatient studies. Most recent articles first. Fluvoxamine, created 37 years ago, is an inexpensive and widely available generic drug. Get your prescription in advance of getting COVID. The study was also featured on 60 Minutes. Medicine today isnt about saving your life. This site requires JavaScript to run correctly. If you cant get a prescription for COVID, then perhaps you have OCD? Steve Kirsch, current director of the Covid 19 Early Treatment fund is an MIT alumni who has made a career as a tech entrepreneur. If you are experiencing any odd adverse reactions, youll need to consult with your doctor ASAP. The race to find covid-19 drug treatments that actually work, The antimalarial drug Trump took for covid might actually be dangerous. Online Status. Try refreshing this page and updating them one That trial has now been completed, and the researchers are analyzing their data. Talking to Kirsch is an exhausting experience. It doesnt get any better than this. Pretty much nothing changed when the Phase 3 trial confirmed fluvoxamine worked. . He considers himself an expert in something that he doesnt have training or experience in, and hes not following scientific methods to assess data.. Steve Kirsch is a high-tech serial entrepreneur based in Silicon Valley. His efforts became more focused on medical research when, in 2007, he was diagnosed with a rare blood cancer. I fully expected both organizations to do absolutely nothing. We didnt come up with better mouse technology than Microsoft did. Reached by email, the two fluvoxamine investigators denied that there was any effort to suppress their research, and they were cautiously optimistic about their continued study. It does not matter how many lives will be saved. He has a BS/MS in Electrical Engineering and Computer Science from MIT. Nobody who took the drug got sick at all, most all wanted to return to work within 3 days after starting treatment. Physicians who use the drug for COVID now swear by it. Zero. 33. Earlier that month, Seftel had heard about fluvoxamine during a presentation by tech entrepreneur Steve Kirsch, whose COVID-19 Early Treatment Fund supports research on existing drugs that could . This is why Cliff doesnt talk to me. The most stunning study of fluvoxamine ever done was at the Golden Gate Fields racetrack in November 2020, right after the WashU trial was published in JAMA. Doctors who have used fluvoxamine in the US and other countries swear by it. The 50mg BID dose was quite effective, but it has to be started early (as soon as symptoms start). NIH and WHO refuse to acknowledge it works since it will cause vaccine hesitancy if it is known that there is a drug that turns COVID into a mild disease. The repository goes over the prescribing guidelines, contraindications, and describes the effect on caffeine consumption while on drug (basically you want to avoid caffeine while on the drug). They all promised me when fluvoxamine passed Phase 3 trials, nearly everyone would use it. More recently, hes adopted extremist positions on covid vaccines, which he alleges are toxic. He has claimed that one in 1,000 people who have received mRNA vaccines have died as a result, and even claimed the vaccines kill more people than they save at an FDA public forum, which was first reported by the Daily Beast. Kirsch is a serial entrepreneur who has spent decades pitching the next big thing, whether optical mice (Mouse Systems), document processing (FrameMaker), search engines (Infoseek), digital. Quick Summary . This story is part of the Pandemic Technology Project, supported by The Rockefeller Foundation. The alarming article cited the claims of two anti-vaxxers, Steve Kirsch and Dr. Robert Malone. Mar. The NIH never did a risk benefit analysis of this drug. Thats pretty typical, but your mileage may vary. People who report not tolerating the drug are typically prescribed too high a dose. Most recent articles first. Early research suggests that fluvoxamine, an FDA approved medication for depression and obsessive compulsive disorder, can be an effective early treatment for COVID-19. 21. The reason is pure corruption. Part of TV News Archive. - Quora, Heres presentation I gave at the re-open California Conference on January 9,2021: How to fix the problemHow to fix the problem Steve Kirsch Executive DirectorCOVID-19 Early Treatment Fund stk@treatearly.org 650-279-1008Google Docs[https://docs.google.com/presentation/d/1-A4y78wv3tTPmVu57FOabY6j-MJbPwMGojKwZfaCkAs/. Consider masks by contrast. But the whole process has gone too slowly for Kirsch. Substitutions. Some countries dont have fluvoxamine so this is the alternative. Proxalutamide and fluvoxamine pushers and the early treatment grift. I asked to give a talk about COVID at MIT, but they couldn't find a faculty member to sponsor it. As a health care journalist, I started off firmly in the wait-and-see camp on mRNA vaccines. With covid, 80% of your patient population does just peachy with no treatment at all, just a little bed rest and fluid. Always be self aware when using fluvoxamine. To scientists, giving fluvoxamine a chance means running a large trialnot giving it to individual patients in the clinic, off-label and outside the context of active data collection and analysis. Read More fluvoxamine The Fluvoxamine FAQ Infoseek lost out to Yahoo; it had a chance to grow bigger, but it didn't. This document is a collection of evidence that highlights the glaring errors in our pandemic response. Ive used it personally at 50mg twice a day and experience no adverse events at all. The drug was widely prescribed as a covid treatment for much of 2020, based on anecdotes and flawed studies. This suggests that a 50mg BID loading dose for day one, followed by 50mg QD dose for the following 13 days should also be quite effective. So there were too few events in the placebo group and they werent recruiting fast enough. Our in-depth reporting reveals whats going on now to prepare you for whats coming next. $1M reward: Do we need more data re: Fluvoxamine for COVID-19? Note that a total of 77 people got the drug, not 65. Dr. Seftel is an NIH-funded researcher and an NIH reviewer. One of the drugs, Fluvoxamine, showed a 30 . So probability of successful Phase 3 can be estimated to be over 99.99% since there are tens of thousands of phase 3 studies. But as Kirsch has clashed with the experts he initially surrounded himself with, hes grown increasingly close to others who share his perspectives on vaccineswho have, in turn, provided a large and receptive audience to his claims about a fluvoxamine conspiracy. As Kirsch has gone deeper into the anti-vaccine scene, many professional associates have increasingly distanced themselves from him. My experience is very typical. He has a history of giving away some of his millions to good causes, and when COVID-19 began. Steve Kirsch: Vaccine Killing Millions, Treatments, VAERS, 5-Month Death Signal, Mystery Clots Embed 7.76K 31 'This Has Cost Millions Of Lives': Steve Kirsch On Suppression Of Repurposed Drugs And A Spike In Deaths 5 Months After Vaccine Rollout By Jan Jekielek American Thought Leaders / The Epoch Times November 24, 2022 Show more Has it really been 25 years, a whole quarter of a century? Fluvoxamine has a 40 year safety track record. There are at least eight mechanisms of action that we think contribute to the effectiveness of this drug. Hes also recently increased the number of Americans he claim have been killed by the vaccine from 25,0000, to 150,000, or even as many as 250,000 Americans. People are dying because of physician fear of a new treatment with a 100% success rate and a solid mechanism of action. Even though they spent only 45 minutes and just reviewed the 2 clinical studies and some plausible mechanisms of action (and ignored anecdotal evidence and multiple retrospective trials, all of which were supportive), after the meeting they voted overwhelmingly (11 to 5 with 4 being neutral) in favor of having doctors talk to their patients about using fluvoxamine if they have COVID using a "shared decision making" process. Where did it go wrong. It is in a class of drugs known as selective serotonin-reuptake inhibitors (SSRIs), but unlike other SSRIs, fluvoxamine interacts strongly with a protein called the sigma-1 receptor. I took it myself at that dosage and noticed zero side effects. And FrameMaker is still a niche product. One of the first CETF grants was to investigate the antimalarial hydroxychloroquine. As trial results rolled in, that mismatch began to put a strain on Kirschs relationship with the funds advisory board. For example, tylenol+caffeine+fluvoxamine can lead to serotonin syndrome. Fluvoxamine public data repository: The fluvoxamine public repository has all the documents related to fluvoxamine for COVID, including the RCT, RWE, observational studies and a link to the 1 hour lecture on serotonin and fluvoxamine. iRobot said it had consent to collect this kind of data from inside homesbut participants say otherwise. On Dr. Drew, he told a story about a friends daughter who had to get an abortion because of damage caused by the shot. You can experience serious side effects if you do not pay attention to interactions such as if you are currently on another SSRI of a different type. Sage Hana. After two weeks (since it was a tight knit community, everyone could see what was happening to the two groups), every track worker who got sick with COVID, demanded the drug. The NIH Guidelines committee is being very slow to react (we have no idea if they are even considering the drug because nobody is allowed to know that because all their deliberations are kept secret). By March 2020, hed settled on the idea of searching for covid treatments in the pre-existing pharmacopeia. The infectious disease scientists lied to me. It could do nothing. Some are views most scientists think are wrong. Several other trials around the world are in the final stages, too. At the end of May this year, Siliciano emailed the other advisors to say that Kirsch had gone off the deep end and he was cutting ties. In California, Silicon Valley tech entrepreneur Steve Kirsch was also thinking about the pandemic. He has been a medical philanthropist for more than 20 years. Here are my answers. Why the FDA should grant an EUA for fluvoxamine immediately, a brilliant op-ed in the Wall Street Journal, "Too much caution is killing COVID patients. If it isn't fluvoxamine preventing hospitalization and long-haul COVID, then if you find what it is, you win. No more. Skirsch.io traffic volume is 1,957 unique daily visitors and their 3,914 pageviews. Kirsch did a lot of things right when he set up CETF. If you start later, doctors use higher dosages and compliance becomes a bigger problem. 47).. When I asked him why so many experts in the field disagreed with him, he alleged there were effortseither malicious or negligentto suppress evidence of cheap, effective covid treatments. He says that Facebook took down one of his posts announcing his appearance on 60 Minutes. The NIH picks the drug that makes the most money for the drug companies regardless of long-term safety Molnupiravir! Things took a final and dramatic turn once Kirsch started claiming the government was covering up vaccine deaths. See this Wall Street Journal op-ed. That is when the phase 2 results were published. This advice is now outdated. ALWAYS check with your doctor and report any medications you are taking before or plan to take after you start taking fluvoxamine. We need to keep people out of the hospital in the first place. Fauci wants the vaccine to be the only option, Cliff Lane works for Fauci, and Cliff follows his orders. By Steve Kirsch Last updated: March 14, 2021 After I appeared on the60 Mi nut es story about fluvoxamine,I've received a lot of questions from people about how to treat COVID. has tons of info on fluvoxamine with all the links. Pretty much nothing changed when the Phase 3 trial confirmed fluvoxamine worked. While these are stunning results, less than a dozen doctors in the US are prescribing fluvoxamine today. The U of M's study focused on three common drugs: ivermectin, metformin, and fluvoxamine. That way you can start immediately. Thanks to the volumes of data and information provided by pharmaceutical companies and regulators, as well as large numbers of trials from independently funded research groups around the world, I now trust that theyre safe for the vast majority of adults. And, according to three members of CETFs scientific advisory board, he put pressure on them to promote fluvoxamine for clinical use without conclusive data that it worked for covid. Its whether Merck can make a killing that matters. Dr. Seftel's paper has been accepted for publication and will appear in OFID in early February. On his blog, Covid-19 Data Science, he has extensivelyand mercilesslyunpacked Kirschs evidence for the vaccine death claims. Jan 17. Immediately after the results of the first fluvoxamine trial were releasedbut before they were published in a peer-reviewed journalhe wrote a post on Medium.com called The Fast, Easy, Safe, Simple, Low-Cost Solution to COVID That Works 100% of the Time That Nobody Wants to Talk About.. The only way to do that is to treat them as early as possible with a drug that prevents hospitalization and death. Server IP cope with resolved: Yes Http reaction code: 200 Response time: 0.27 sec. After publication of the recommendation in December 2021, the NIH did absolutely nothing change their recommendation. I agreed to do it partially because I respect Bob [Siliciano] so much, and partially because I thought the concept was excellent, said former board member Doug Richman, a prominent HIV drug researcher at the University of California San Diego and former member of the funds scientific advisory board. It is about following orders and making money for the drug companies and protecting the doctor from liability and losing his medical license. Fluvoxamine was reportedly added to just 2 practice guidelines (Ontario and Johns Hopkins). What happens when your prescription drug becomes the center of covid misinformation. Early treatment with existing drugs is the fastest, most effective, and lowest. Saving the world has been a theme of Kirschs life for years. My website www.skirsch.io has tons of info on fluvoxamine with all the links. Answer (1 of 2): Yes, In a preliminary study of COVID-19 patients with mild-to-moderate disease who were attempting to recover in their homes, researchers at Washington University School of Medicine in St. Louis have found that the drug fluvoxamine seems to prevent some of the most serious compli. Kirsch: Yes, but you could easily watch that 60 Minutes story and believe that we need more data before people should start using fluvoxamine. And that is what has allowed Kirsch, and people like him, to become so influential. After boosting unproven covid drugs and campaigning against vaccines, Steve Kirsch was abandoned by his team of scientific advisersand left out of a job. Dosing. They immediately ruled out the vaccine, because the vaccine is, quote, safe.. Mr. Steve Kirsch - A philanthropist and former Silicon Valley tech executive. There may be a depression of libido while on drug, but since the drug is taken on acute basis, this is only temporary and it reverses once the drug is stopped. Doctors wait for government permission (EUA or added to the NIH guidelines) before using a drug. , or the patient is simply sensitive to the drug (50mg twice a day can be too much for some people). One user reported dilated pupils and increased heart rate (which could be nerves about the dilated pupils). My website. In two trials (both published studies in peer reviewed journals with Editor's Choice in both cases), the drug had a 100% effect size in protecting against hospitalization from the respiratory symptoms from COVID. It has enrolled only 130 people in the first month and is enrolling only 70 per week now. After publication of the recommendation in December 2021, the NIH did absolutely nothing change their recommendation. To protect M10 from my COVID-19 vaccination opinions, I will no longer post about my vaccination concerns here.. 1 hr ago. So you can address your OCD and if you get COVID, youll can up the dose. Here is what, e) which concluded: Under a variety of assumptions, fluvoxamine shows a high probability of preventing hospitalization in outpatients with COVID-19., For more about fluvoxamine (and other SSRIs that work), see, fluvoxamine completed a Phase 3 study showing it works that was published in the Lancet Global Health, NIH basically dismissed the fluvoxamine study as I predicted they would, few people werent afraid of expressing their displeasure, the highly acclaimed Bangladesh mask study showed, Johns Hopkins has incorporated fluvoxamine in their treatment guidelines, Ontario has become the first province to list fluvoxamine as a treatment doctors can consider for patients. None of this would really matter if Kirschs views on vaccinations were private, or shared with a limited audience. Flavio Cadegiani and Steve Kirsch's studies didn't make the cut. But they dont want their names used. Im just telling you the truth. Decreasing the dosage or stopping the medication will mitigate symptoms within hours. Once the Phase 2 result came out, it should have been embraced by doctors. The FDA is will take months to deliberate on the fluvoxamine EUA application that we submitted on January 29. Medicine isnt about saving lives anymore. It is very important to educate doctors because most people rely on their doctors for advice. A video presentation by Steve Kirsch, Executive Director of the Covid-19 Early Treatment Fund. The NIH did nothing despite the fact the that NIH, FDA, CDC, and academic institutions participated in the panel. This was shown to be very tolerable (no side effects in 99% of patients) and extremely effective (no hospitalizations and death if you start it ASAP after first symptoms). The ICER independent review showed fluvoxamine is more effective than Molnupiravir: Read this article I wrote about using fluvoxamine correctly for COVID. This post was written to memorialize the corruption. I bumped up the reward to $1M. We report a real-world experience using fluvoxamine for coronavirus disease 19 (COVID-19) in a prospective cohort in the setting of a mass outbreak. Theyre finding alternative leaders to follow, Morris said. On January 22, 2021, thirty key opinion leaders (KOL) from NIH, CDC, and leading academic institutions met to review the evidence for using fluvoxamine for treating COVID. By the beginning of September, he was no longer the companys CEO, replaced by his co-founder, Marten Nelson. S1R can essentially turn off IRE1, so IRE1 will not activate XBP1, so that the cytokine production will decrease.
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